SolvedHow-toUpdated

The Binding of Isaac: Rebirth: Guide How to Unlock ALL 641 Achievements

Short answer

In this guide, you can find ways to achieve something new in the game and unlock it.

Steam Community guide by Mamon.

Translation

The author of this guide does not speak English. However, I did my best to translate everything using a translator and Wiki. I would be very grateful for any help with writing or for support in the form of Steam points. Thank you!
↓ Original ↓
https://steamcommunity.com/sharedfiles/filedetails/?id=3408959992

Introduction


In this guide, you can find ways to achieve something new in the game and unlock it.
If you find a way to have suggestions for improvement, the comments are open.

Characters

Isaac



unlocked by default
UnlockTarget

Boss Rush

Mom's Heart

Satan

Isaac

???

The Lamb

Ultra Greed

Ultra Greedier

Hush

Mega Satan

Delirium

Mother

The Beast

Completion Marks

Magdalene



Have 7 or more Red Heart
containers at one time.
UnlockTarget

Boss Rush

Mom's Heart

Satan

Isaac

???

The Lamb

Ultra Greed

Ultra Greedier

Hush

Mega Satan

Delirium

Mother

The Beast

Completion Marks

Cain



Hold 55 Coins at one time
UnlockTarget

Boss Rush

Mom's Heart

Satan

Isaac

???

The Lamb

Ultra Greed

Ultra Greedier

Hush

Mega Satan

Delirium

Mother

The Beast

Completion Marks

Judas



Defeat Satan
UnlockTarget

Boss Rush

Mom's Heart

Satan

Isaac

???

The Lamb

Ultra Greed

Ultra Greedier

Hush

Mega Satan

Delirium

Mother

The Beast

Completion Marks

???



Defeat Mom's Heart 10 times
UnlockTarget

Boss Rush

Mom's Heart

Satan

Isaac

???

The Lamb

Ultra Greed

Ultra Greedier

Hush

Mega Satan

Delirium

Mother

The Beast

Completion Marks

Eve



Don't pick up any Hearts for 2 floors in a row
UnlockTarget

Boss Rush

Mom's Heart

Satan

Isaac

???

The Lamb

Ultra Greed

Ultra Greedier

Hush

Mega Satan

Delirium

Mother

The Beast

Completion Marks

Characters

Samson



Complete 2 floors in a row without taking damage
UnlockTarget

Boss Rush

Mom's Heart

Satan

Isaac

???

The Lamb

Ultra Greed

Ultra Greedier

Hush

Mega Satan

Delirium

Mother

The Beast

Completion Marks

Lazarus



Have 4 or more Soul Hearts at one time
UnlockTarget

Boss Rush

Mom's Heart

Satan

Isaac

???

The Lamb

Ultra Greed

Ultra Greedier

Hush

Mega Satan

Delirium

Mother

The Beast

Completion Marks

Azazel



Make 3 Deals with the Devil in one run
UnlockTarget

Boss Rush

Mom's Heart

Satan

Isaac

???

The Lamb

Ultra Greed

Ultra Greedier

Hush

Mega Satan

Delirium

Mother

The Beast

Completion Marks

Eden



Complete Chapter 4
UnlockTarget

Boss Rush

Mom's Heart

Satan

Isaac

???

The Lamb

Ultra Greed

Ultra Greedier

Hush

Mega Satan

Delirium

Mother

The Beast

Completion Marks

The Lost



Die in a Sacrifice Room while holding Missing Poster
UnlockTarget

Boss Rush

Mom's Heart
![](https://images.steamus

Did this work for you?

More for The Binding of Isaac: Rebirth

All The Binding of Isaac: Rebirth guides →

SolvedHow-to

Using MODs Online

Hello there guys, so with a little of search i discovered how to use mods in online, i will show you step by step in this guide.

#multiplayer#mods

SolvedHow-to

Best Mods for the Game

Lo que se intenta hacer con esta guía es facilitar a los nuevos jugadores el utilizar mods para mejorar su experiencia de juego, incluyendo algunos mods visuales por mera diversión. Los mismos no son obligatorios de usar, cada uno hace lo que quiera con su juego. The intention of this guide is to…

#save#mods

SolvedHow-to

Unlocking Everything in the Binding of Isaac (Repenting Update!)

This is not your ordinary "list all 637 achievements and their descriptions" guide. The achievement descriptions of The Binding of Isaac are sometimes incredibly vague so I made an in-depth method for unlocking every single item, character, trinket, floor, etc in The Binding of Isaac: Rebirth…

#save#audio#achievement#quest

SolvedHow-to

Optimal Path to Dead God on a New Save File

NOTE: CONTAINS MANY SPOILERS This guide is designed to help you get the Dead God Achievement (100% completion) in the most optimal way on a new save file, by unlocking the strongest items first and holding off on unlocking weaker items until later to avoid diluting the item pool. This will cover…

#save#mods#achievement

SolvedHow-to

Guía Que Desbloqueos Priorizar 𐕣 (Rep+)

Esta Guía busca recopilar los mejores desbloqueos de personajes, desafíos y logros en general. Esto puede ayudarte a priorizar ciertos objetos para tener mejores runs, como por ejemplo, con Tainted The Lost. Esta guía se basa en mi criterio y conocimiento del juego, cualquier duda o corrección es…